Gene | Source | In gene/distance | PCSL | Expression | p-value |
|---|
ATPAF1
|
In vitro
| yes | none | over | 0.002 |
GCOM1
|
In vivo
| yes | none | under | 0.003 |
MEX3D
|
In vivo
| 32,561 | 19p13.3 | over | 9.70E-04 |
PTRF
|
In vivo
| 62,474 | 17q21-22 | under | 0.003 |
TRPM4
|
In vitro
| yes | near 19q13.4 | over | 1.13E-04 |
- Candidate AIPC genes identified from provirus integration sites recovered from both the in vitro mutagenesis screen and the in vivo subcutaneous tumor model. Source indicates whether the gene was identified from the in vitro screen or the in vivo screen. In gene/distance indicates whether the LV provirus was within the gene transcription unit, or if outside the transcription unit indicates the distance in base pairs from the proviral integration to the transcription start site of the gene. PCSL indicates if the provirus was within or near a PCa susceptibility locus. Expression indicates if the gene was over or under-expressed in PCa tissue using the Oncomineâ„¢ database. Rank is the Oncomineâ„¢ ranking of over or under-expressed genes. p-value is the Oncomineâ„¢ p-value for over or under-expression.
