Figure 6

miR-300 expression is inversely correlated with Twist expression and metastasis in primary tumors from patients with oral cancer. A. The grey dotted line and the solid grey line indicated the median value of miR-300 and Twist. Expression either above or below the median was considered as “high” and “low,” respectively. Significant inverse correlation was observed between miR-300 and Twist in patient specimens (R = -0.367, P = 0.001). White boxes indicated cases with inverse expression pattern of miR-300 and Twist (n = 47), while shaded boxes showed cases with no inverse relationship between miR-300 and Twist (n = 28). B. The miR-300 expression level in metastasis-positive patients was significantly lower (P = 0.033) than that in metastasis-negative patients. C. The Twist expression level in metastasis-positive patients was significantly higher (P = 0.041) than that in metastasis-negative patients.