Figure 3
From: USP18 is crucial for IFN-γ-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity
USP18 function in tumor growth depends on the immune system. 3 × 105 B16-OVA-USP18 or B16-OVA-GFP tumor cells were intravenously inoculated into NSG mouse. The tumor burden (A-B) and mice survival rate (C) were analyzed. 3 × 105 B16-OVA-USP18 or B16-OVA-GFP tumor cells were intravenously inoculated into C57BL/6 mice with or without depletion of CD8+ or CD4+ T cells, or NK1.1+ NK cells, and the tumor burden in the lung was monitored (D-E). 3 × 105 B16-OVA-GFP, or B16-OVA-USP18 tumor cells were intravenously inoculated into C57BL/6, or Ifng-/- B6 mice. Tumor growth was monitored (F-G).