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Table 1 Frequencies of KRAS mutations in 1267 colorectal cancer cases

From: Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review

Codon Nucleotide change Amino acid change Codon change No. of cases Proportion among 1267 cases
Any Any Any Any 505 40%
12 Any Any Any 344 27%
13 Any Any Any 115 9.1%
61 Any Any Any 19 1.5%
146 Any Any Any 40 3.2%
Mutations identified in only one of codons 12, 13, 61 and 146   
12 c.34G>A p.G12S GGT>AGT 12 1.0%
12 c.34G>C p.G12R GGT>CGT 7 0.6%
12 c.34G>T p.G12C GGT>TGT 43 3.4%
12 c.35G>A p.G12D GGT>GAT 157 12%
12 c.35G>C p.G12A GGT>GCT 20 1.6%
12 c.35G>T p.G12V GGT>GTT 93 7.3%
12 c.35_36delinsCA p.G12A GGT>GCA 1 0.1%
13 c.37G>C p.G13R GGC>CGC 1 0.1%
13 c.37G>T p.G13C GGC>TGC 2 0.2%
13 c.38G>A p.G13D GGC>GAC 103 8.1%
13 c.38G>T p.G13V GGC>GTC 2 0.2%
61 c.182A>G p.Q61R CAA>CGA 2 0.2%
61 c.182A>T p.Q61L CAA>CTA 4 0.3%
61 c.183A>C p.Q61H CAA>CAC 7 0.6%
60, 61 c.180_181delinsAA p.Q61K GGT + CAA>GGA + AAA 4 0.3%
146 c.436G>A p.A146T GCA>ACA 21 1.7%
146 c.436G>C p.A146P GCA>CCA 3 0.2%
146 c.437C>T p.A146V GCA>GTA 11 0.9%
Mutations identified in two or more of codons 12, 13, 61 and 146   
12, 13 c.35G>A, c.38G>A p.G12D, p.G13D GGT>GAT, GGC>GAC 4 0.3%
12, 13 c.35G>T, c.37G>T p.G12V, p.G13C GGT>GTT, GGC>TGC 1 0.1%
12, c.35G>T, p.G12V, GGT>GTT, GGT + CAA>GGA + AAA 1 0.1%
60, 61 c.180_181delinsAA p.Q61K
12, 146 c.34G>C, c.436G>A p.G12R, p.A146T GGT>CGT, GCA>ACA 1 0.1%
12, 146 c.34G>T, c.436G>A p.G12C, p.A146T GGT>TGT, GCA>ACA 1 0.1%
12, 146 c.34G>T, c.437C>T p.G12C, p.A146V GGT>TGT, GCA>GTA 1 0.1%
12, 146 c.35G>T, c.436G>A p.G12V, p.A146T GGT>GTT, GCA>ACA 1 0.1%
13, 146 c.38G>A, c.436G>A p.G13D, p.A146T GGC>GAC, GCA>ACA 1 0.1%
12, 13, 61 c.35G>A, c.38G>A, c.183A>T p.G12D, p.G13D, p.Q61H GGT>GAT, GGC>GAC, CAA>CAT 1 0.1%