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Figure 1 | Molecular Cancer

Figure 1

From: Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents

Figure 1

R clones are resistant to 50 μM cytarabine. WST-8 cell proliferation assay of 5 MCL cell lines (CTRL) and 5 R clones was carried out as described in Methods. While the lethal dose of cytarabine for CTRL cells ranged from 0.05 to 0.4 μM, proliferation rate of R clones in 50 μM araC was virtually unaffected. Representative example of two independent experiments is shown. Standard deviations were < 5% for all measurements.

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Molecular Cancer

ISSN: 1476-4598