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Figure 6 | Molecular Cancer

Figure 6

From: Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents

Figure 6

Experimental therapy of mice xenografted with JEKO-1 CTRL and JEKO-1 R cells. Overall survival of experimental animals is shown as Kaplan-Meier survival estimates. Loss of anti-tumor activity was observed for the nucleoside analogs fludarabine and gemcitabine in the therapy of R clone-xenografted mice (dashed lines) when compared to CTRL-xenografted mice (solid lines). Other classes of anti-lymphoma agents retained the antitumor activity in both CTRL- and R clone-xenografted mice. Individual cohorts contained 6 animals. For more details see Methods.

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Molecular Cancer

ISSN: 1476-4598