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Figure 5 | Molecular Cancer

Figure 5

From: Challenging the roles of CD44 and lipolysis stimulated lipoprotein receptor in conveying Clostridium perfringens iota toxin cytotoxicity in breast cancer

Figure 5

CD44 confers resistance through inhibition of endocytosis. (A) SUM1315mo LSR knockdown and CD44 overexpressing cells were treated with Ia only or iota toxin for 30 min, followed by lysosome imaging. A minimum of fifteen fields was viewed per treatment per experiment. (B) SUM1315mo LSR knockdown and overexpressing and CD44 overexpressing cells were treated with Ia or Ia + Ib for 4 h. Cells were washed, lysates were isolated and analyzed via western blot using an Ib-specific antibody; α-tubulin was used as a loading control. Representative western blot and corresponding intensity were measured via ImageJ.

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Molecular Cancer

ISSN: 1476-4598