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Table 2 Iota toxin sensitivity of breast cancer cells following oleic acid treatment

From: Challenging the roles of CD44 and lipolysis stimulated lipoprotein receptor in conveying Clostridium perfringens iota toxin cytotoxicity in breast cancer

Cell line

Ia (10 ng/ml)

Ia (10 ng/ml) + Ib (20 ng/ml)

Ia (25 ng/ml) + Ib (50 ng/ml)

Ia (50 ng/ml) + Ib (100 ng/ml)

Ia (100 ng/ml) + Ib (200 ng/ml)

T47D

-

+

+

+

++

T47D + Oleic acid

-

++

++

++

++

SUM190

-

-

+

+

+

SUM190 + Oleic acid

-

-

+

++

++

  1. (−) Resistant, 0 to 10% cell rounding; (+) Sensitive, 11 to 50% cell rounding; (++) Highly Sensitive, >50% cell rounding. Toxin Sensitivity at 8 h post treatment.