Figure 6
From: Aldolase positively regulates of the canonical Wnt signaling pathway
A hypothetic model for the role of the Aldolase proteins in Wnt signaling stimulation. (A) In the absence of Wnt stimulation, β-catenin is degraded by a dedicated cytoplasmic “β-catenin degradation protein complex” (B) in cells that express high levels of the Aldolase proteins, Aldolase binds GSK-3β, the “β-catenin degradation protein complex” is disassembled, disheveled and Axin re-localize to the membrane and the Wnt cascade is activated.