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Figure 5 | Molecular Cancer

Figure 5

From: miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25

Figure 5

USP25 functions as a metastasis promoter and its molecular mechanism. (A) The protein levels of USP25 were determined by western blot analyses after transfection with si-USP25 or a negative control in SPC-A-1sci, A549, H1299 cells, β-actin served as an internal control. (B-D) Transwell migration and invasion assays for SPC-A-1sci, A549, and H1299 cells were performed after transfection with si-USP25 or a negative control. (E) Transwell migration and invasion assays for SPC-A-1-miR-control and SPC-A-1-anti-miR-200c cells were performed after transduction with si-USP25 or a negative control. The results are representative of at least three independent experiments. Statistical analysis was performed using Student’s t- test. Error bars represent S.E.M. *P < 0.05; **P < 0.01; ***P < 0.001.

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Molecular Cancer

ISSN: 1476-4598