APC-Cldn1 mice demonstrate increased colonic permeability and bacterial translocation into the mucosa. Permeability was determined to FITC-dextran via rectal administration (A) at 6 - 8 weeks (n = 6) and (B) 14–16 weeks of age in APC and APC-Cldn1 mice (n = 7). (C) qRT-PCR analysis of 16S rDNA in the distal colon of APC and APC-Cldn1 mice at 16 weeks of age (n = 3 mice in each group). Values are mean ± S.E.M. *p < 0.05.