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Table 2 Microarray analysis of APC-Cldn1 versus APC Min mice tumors

From: Claudin-1 overexpression in intestinal epithelial cells enhances susceptibility to adenamatous polyposis coli-mediated colon tumorigenesis

Signaling gene symbol p-value Fold change
A. Wnt signaling related genes
Tcf4 0.068 1.581
Lef1 0.017 2.238
Fzd10 0.016 2.219
Axin2 0.040 1.693
Wnt6 0.022 1.886
Wnt10a 0.125 1.911
Sox17 0.064 2.694
Ephb6 0.029 2.527
B. Notch signaling related genes
Tcf4 0.068 1.581
Lef1 0.017 2.238
Fzd10 0.016 2.220
Axin2 0.040 1.694
Mmp9 0.042 1.628
Atoh1 0.047 -3.487
Klf4 0.010 -2.495
Muc2 0.112 -2.141
Muc3 0.002 -6.700
Muc4 0.345 -1.590
Tff3 0.184 -1.789
C. lnflammation/lmmune response genes
lL23a, p19 0.011 2.250
CxcI5 0.060 2.392
CxcI9 0.134 2.394
CxcI2 0.462 1.548
Mmp9 0.042 1.628
Nfat5 0.031 1.515
Pla2g5 0.002 2.796
Retn1b 0.045 10.865
Lcn2 0.001 1.894
Ccl6 0.075 1.658
Ccl28 0.002 5.352
Ccl3 0.001 1.894
IL1b 0.048 1.825
Csf3r 0.056 1.567
Akt2 0.001 1.541
H2-AA 0.017 1.764
H2-Eb1 0.051 1.666
CD244 0.010 -2.207
Tff3 0.184 -1.790
Muc2 0.112 -2.141
  1. Differentially expressed genes (DEGs) altered with claudin-1 overexpression, with at least 1.5 fold change, involved in (A) Wnt Signaling (B) Notch-signaling or (C) Inflammation/Immune response (nā€‰=ā€‰3 mice in each group).