A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma

Siraj, Abdul K; Bu, Rong; Prabhakaran, Sarita; Bavi, Prashant; Beg, Shaham; Al Hazmi, Mohsen; Al-Rasheed, Maha; Alobaisi, Khadija; Al-Dayel, Fouad; AlManea, Hadeel; Al-Sanea, Nasser; Uddin, Shahab; Al-Kuraya, Khawla S

doi:10.1186/1476-4598-13-168

Molecular Cancer

Table 3 Clinical information, pathologic diagnosis, BRAF and KRAS testing results

From: A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma

Case #	AGE	Gender	Histology Type	Site	Grade	Stage	*BRAF*	*KRAS*	CIMP	MSI-PCR	Pre-existing
Case #	AGE	Gender	Histology Type	Site	Grade	Stage	*BRAF*	*KRAS*	CIMP	MSI-PCR	Adenoma
BRAF-1	60	Male	AC	Caecum	2	I	V601E	Codon 13	Low CIMP	MSI-L	Tubular adenoma
BRAF-2	47	Male	AC	Ascending colon	2	I	V600E	Codon 13	NA	MSI-S	Hyperplastic polyp
BRAF-2	47	Male	AC	Ascending colon	2	I	V600E	Codon 13	NA	MSI-S	SERRATED ADENOMA
BRAF-3	71	Female	AC	Rt colon	1	III	V600E	WT	NA	MSI-H	Unremarkablemucosa
BRAF-4	57	Female	AC	Rt colon	3	IV	V600E	WT	Low CIMP	MSI-S	Unremarkablemucosa
BRAF-5	67	Male	AC	Recto sigmoid	2	II	V600E	WT	Low CIMP	MSI-S	Unremarkablemucosa
BRAF-6	74	Female	AC	Rt colon	3	II	V600E	WT	Low CIMP	MSI-H	Unremarkablemucosa
BRAF-7	66	Male	AC	Ascending colon	2	III	V594G	WT	Low CIMP	MSI-L	Adenoma
BRAF-8	68	Male	AC	Rt colon	2	IV	V600E	WT	Low CIMP	MSI-S	Unremarkablemucosa.
BRAF-9	61	Female	AC	Rt colon	1	I	V600E	WT	High CIMP	MSI-H	Small hyperplasticpolyps
BRAF-10	46	Male	AC	Sigmoid	2	I	V600E	WT	NA	MSI-L	Hyperplastic polyp
BRAF-11	34	Male	AC	Recto sigmoid	2	III	V600E	WT	Low CIMP	MSI-S	Unremarkablemucosa
BRAF-12	71	Male	AC	Sigmoid	2	III	V600E	WT	NA	MSI-S	Hyperplastic polyp
BRAF-13	59	Male	AC	Rectal	2	III	V600E	WT	High CIMP	MSI-S	Tubular adenoma
BRAF-14	66	Female	AC	Rt colon	2	II	V600E	WT	NA	MSI-H	Unremarkable mucosa
BRAF-15	66	Male	AC	Sigmoid colon	2	II	V600E	WT	Low CIMP	MSI-S	No colonic mucosa seen
BRAF-16	73	Female	AC	Rt colon	3	II	V600E	WT	High CIMP	MSI-H	Unremarkable mucosa
BRAF-17	72	Male	AC	Rt colon	2	II	V600E	WT	High CIMP	MSI-H	Unremarkable mucosa
BRAF-18	74	Female	AC	Sigmoid colon	2	II	V600E	WT	NA	MSI-L	Unremarkable mucosa
BRAF-19	55	Female	MC	Recto sigmoid	2	III	V600E	WT	NA	MSI-L	Unremarkable mucosa

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ISSN: 1476-4598

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