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Figure 4 | Molecular Cancer

Figure 4

From: Influence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer does not rely on WNT signaling

Figure 4

Influence of SFRP1 on carcinogenic properties does not rely on canonical Wnt signaling. A) Luciferase assays showed neither changes in Wnt signaling activity upon SFRP1 knockdown in breast cancer cells grown in standard medium (left 3 rows), nor in breast cancer cells grown in starvation medium followed by Wnt stimulation using LiCl treatment (right 3 rows). B) Immunofluorescence analysis showed no changes in cellular localization of β-Catenin after SFRP1 knockdown. C/D) mRNA levels of known canonical Wnt target genes (C) as well as members of the non-canonical Wnt signaling pathway (D) revealed no significant changes upon SFRP1 knockdown. E) mRNA levels of EMT related genes after SFRP1 knockdown. F) Model of action of SFRP1 in breast cancer.

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Molecular Cancer

ISSN: 1476-4598