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Figure 7 | Molecular Cancer

Figure 7

From: Circulating mouse Flk1+/c-Kit+/CD45- cells function as endothelial progenitors cells (EPCs) and stimulate the growth of human tumor xenografts

Figure 7

EPC effects the vasculature in U251 xenografts. (A) U251 Xenograft Growth Curve: Local injection of U251 only (red) or U251 tumor cells combined with EPC_acLDL cells (blue) at day 0 (arrow); Tumor Efficiency: Control 3/5 tumors; EPC_acLDL 5/5 tumors (n=5, each arm) (B) U251 Xenograft Growth Curve: Systemic injection (1:10) of U251 only (red) or U251 tumor cells combined with EPC_acLDL cells (blue) at day 7 (arrow); Tumor Efficiency: Control 4/5 tumors; EPC_acLDL 6/6 tumors (n=5-6, each arm) (C) U251 tumor xenografts with systemic injection of EPC_acLDL (1:10 ratio) collected at day 28: Representative slides stained: red, CD31; blue, Hoechst's 33258. (D) Quantification of Mean Vessel Density: Mean number of CD31+ pixels per 0.1 mm2 and standard deviation between control tumors and tumors with systemic injection of EPC_acLDL (n=3).

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Molecular Cancer

ISSN: 1476-4598