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Figure 7 | Molecular Cancer

Figure 7

From: IL-1β-induced activation of p38 promotes metastasis in gastric adenocarcinoma via upregulation of AP-1/c-fos, MMP2 and MMP9

Figure 7

IL-1β stimulation increases the metastatic potential of GA cells in vivo via a p38–dependent mechanism. A: Representative lung metastases formed in different group mouse. B: Bars indicated the number of animals developed lung metastases. C: Representative results of HE staining of lung metastases. D: Bars indicated the mean ± SD number of metastatic foci in 6 of lung sections/per lung in mice that had developed lung metastases. △△P < 0.05 vs. injected with scramble siRNA transfected cells plus IL-1β stimulation. E: RT-PCR analysis of p38, MMP2, MMP9 and c-fos mRNA expression in the lung metastases of different mice. F: IHC analysis of p-p38, MMP2, MMP9 and c-fos protein expression in the lung metastases; IL-1β induced elevated p-p38, MMP2, MMP9 and c-fos protein expression.

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Molecular Cancer

ISSN: 1476-4598