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Figure 4 | Molecular Cancer

Figure 4

From: A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice

Figure 4

Binding sites for transcription factors and regulatory proteins in the murine and the human Rb1 promoter (below the line) and position of the reported indel polymorphisms (above line). TF binding sites in murine sequence as predicted by MatInspector software [33, 34] and as annotated by Zacksenhaus [32] (Genebank Acc.-No. M86180). TF binding sites in human sequence as predicted by [36]. Promoter core consisting of steroid hormone response elements (HRE) and Sp1, ATF and E2F binding sites are highly conserved. Retinoblastoma control elements (RCE) in the human promoter are according to [36] and predicted in the murine promoter using published RCE core sequences [48].

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Molecular Cancer

ISSN: 1476-4598