Figure 5From: Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axisPfn1 interacts with SIRT3 directly. (A) In vitro GST-pull-down assay. (B) Co-immunoprecipitation assay to verify in vivo interaction between Pfn1 and SIRT3. (C) Transfection of exogenous Pfn1 resulted in increased SIRT3 expression.Back to article page