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Figure 6 | Molecular Cancer

Figure 6

From: Clinical relevance and therapeutic potential of angiopoietin-like protein 4 in hepatocellular carcinoma

Figure 6

ANGPTL4 suppressed the motility of HCC. (A) Western blot analysis of ROCK1 protein in tumor xenograft between Ad-ANGPTL4 treatment group and the Ad-Luc control group. Up-regulation of ANGPTL4 protein by Ad-ANGPTL4 treatment was validated in Figure 5C. (B) The effect of rANGPTL4 protein on formation of polymerized stress fibers in HCC cells, indicated by immunostaining of F-actin using rhodamine-phalloidin probe. Red color, F-actin signal; Blue color, nucleic staining by DAPI. The level of ANGPTL4 protein in cells and medium was determined by Western blot analysis (C) Scanning electron microscopy of the morphology of HCC cells after administration of rANGPTL4 protein. Red arrows indicate the formation of extracellular “hair-like” stress fibers. (D) Western blot analysis of ROCK1 protein in MHCC97L cells after administration of rANGPTL4 protein.

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Molecular Cancer

ISSN: 1476-4598