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Table 3 Cox proportional hazard regression analysis of ANGPTL4 mRNA and clinicopathological parameters in relation to the overall and disease-free survivals of HCC patients after hepatectomy

From: Clinical relevance and therapeutic potential of angiopoietin-like protein 4 in hepatocellular carcinoma

 

Univariable analysis

Multivariable analysis

 

HR (95% CI)

P

HR (95% CI)

P

1. Overall survival

    

ANGPTL4 mRNA

    

  Downregulation vs Non-downregulation

2.39(1.33-4.27)

0.003**

1.48(0.81-2.72)

0.204

pTNM staging

    

  Advanced vs early

5.37(2.25-12.81)

0.000***

2.26(0.71-7.18)

0.168

Venous infiltration

    

  Presence vs absence

4.41(2.25-8.67)

0.000***

2.11(0.88-5.09)

0.096

AFP level

    

  >20 ng/ml vs ≤20 ng/ml

3.10(1.60-5.99)

0.001**

2.12(1.07-4.21)

0.031*

2. Disease-free survival

    

ANGPTL4 mRNA

    

  Downregulation vs Non-downregulation

1.83(1.12-2.99)

0.017*

1.40(0.84-2.32)

0.201

pTNM staging

    

  Advanced vs early

2.87(1.57-5.24)

0.001**

1.33(0.53-3.35)

0.544

Venous infiltration

    

  Presence vs absence

3.14(1.84-5.37)

0.000***

2.36(1.06-5.26)

0.036*

  1. Abbreviations: HR hazard ratio, CI confidence interval; *, p<0.05; **, p<0.01; ***, p<0.001.