Figure 6
From: The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation
A model of CXCR7-EGFR Interaction. CXCR7 signals through β-arrestin2, which mediates interaction of CXCR7 with EGFR and activation of EGFR mediated signaling. In some instances CXCR7 might activate mitogenic signaling independently from EGFR (and vice versa). This EGFR transactivation, which occurs in a CXCR7-ligand independent fashion, induces proliferation effects in breast cancer cells.