Figure 2
From: Tax impairs DNA replication forks and increases DNA breaks in specific oncogenic genome regions
Tax blocks DNA replication fork progression. (A-B) Box and whisker plots. Box: 25–75 percentile range. Whiskers: 5–95 percentile range. More than 300 values coming from 3 independent experiments were compiled. Statistical analysis was performed using the non-parametric Mann–Whitney rank sum test. ns: not significant. *: p < 0.05; **: p < 0.01; ****: p < 0.0001. (A): Measurement of acceleration and deceleration of replication forks, IdU/CldU ratio. (B): Analyses of the center-to-center distance which reflects the distance between two replication origins and is indicative of origin firing frequency.