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Table 2 DEK binds to DNA with motifs for major transcriptional regulators

From: The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation

Motif

Motif e value

Match

Match P value

AGGAARH

1.5 × 10−41

PU.1

0.000013

DAAATR

5.6 × 10−22

-

-

CMCMGCC

9.3 × 10−20

SP1

0.000019

ACACASR

1.3 × 10−18

-

-

KTTTCY

1.5 × 10−13

-

-

CHGCMGCC

6.7 × 10−12

-

-

CTTCCBS

3.0 × 10−9

PU.1

0.000006

CAGCKCC

1.0 × 10−8

-

-

TWTAWA

3.4 × 10−8

-

-

MTGTGGY

6.9 × 10−6

RUNX1

0.000017

CACGTG

4.5 × 10−5

USF1

0.000001

CCCCACCC

3.5 × 10−3

SP1

0.000044

CTGTCACY

7.6 × 10−3

-

-

  1. Motif analysis of the sequences bound by DEK, identifying the most common motif not as a unique DEK motif but as that of the transcription factor PU.1. The motif E value denotes the statistical significance of the enrichment of the motif among the DEK-bound sequences. The match p value denotes the statistical significance of the match between the enriched motif and that of the matching transcription factor. Nucleotide sequences are described using standard IUPAC nomenclature, where B denotes C/G/T, D denotes A/G/T, H denotes A/C/T, K denotes G/T, M denotes A/C, R denotes A/G, S denotes C/G, W denotes A/T and Y denotes C/T.