Table 2 Univariate Cox regression analysis for DFS

Age at diagnosis, years

>50 vs ≤50

237

0.9 [0.57-1.4]

0.636

2366

1.01 [0.87-1.16]

0.923

Histological type

ILC vs IDC

59

0.00 [0.00- Inf]

0.837

624

1.09 [0.71-1.67]

0.269

MED vs IDC

0.45 [0.06-3.35]

0.53 [0.20-1.42]

MIX vs IDC

0.00 [0.00- Inf]

0.44 [0.18-1.06]

other vs IDC

1.90 [0.44-8.10]

1.04 [0.57-1.92]

Histological grade

2-3 vs 1

270

3.63 [1.32-9.92]

1.22E-02

2552

2.36 [1.86-3.01]

2.84E-12

Pathological tumor size

pT2-3 vs pT1

155

2.33 [1.27-4.26]

6.01E-03

1744

1.52 [1.29-1.8]

6.83E-07

Pathological axillary lymph node status

positive vs negative

194

2.23 [1.34-3.72]

2.01E-03

2365

1.45 [1.26-1.68]

3.95E-07

ESR1 expression status

positive vs negative

343

0.38 [0.25-0.58]

5.02E-06

3355

0.56 [0.5-0.63]

<2.0E-16

PGR expression status

positive vs negative

343

0.56 [0.38-0.83]

3.86E-03

3353

0.7 [0.63-0.79]

2.24E-09

ERBB2 expression status

positive vs negative

343

1.98 [0.92-4.26]

0.079

3355

1.4 [1.18-1.65]

7.22E-05

Triple-negative expression status

yes vs no

343

2.19 [1.51-3.18]

3.82E-05

3354

1.7 [1.49-1.94]

1.22E-15

B. Gene expression signatures

70-gene GES [11]

Poor vs Good

343

1.22 [0.74-2.02]

0.435

3355

1.83 [1.57-2.12]

3.00E-15

GGI [14]

Poor vs Good

283

1.42 [0.92-2.2]

0.113

2655

2.1 [1.82-2.43]

<2.0E-16

RS [46]

Intermediary vs Good

343

2.73 [1.40-5.31]

1.09E-03

3355

1.63 [1.38-1.93]

<2.0E-16

Poor vs Good

3.03 [1.68-5.46]

2.15 [1.87-2.47]

ROR [41]

Intermediary vs Good

343

1.28 [0.69-2.36]

8.74E-03

3355

1.75 [1.45-2.10]

<2.0E-16

Poor vs Good

1.85 [1.24-2.75]

2.11 [1.85-2.41]

Immune response metagene [50]

Poor vs Good

343

1.17 [0.82-1.68]

0.387

3354

1.19 [1.06-1.34]

2.93E-03

LCK metagene [49]

Poor vs Good

343

1.12 [0.78-1.6]

0.541

3355

1.1 [0.96-1.26]

0.152

Kinase immune metagene [48]

Poor vs Good

343

1.14 [0.78-1.65]

0.507

3355

1.04 [0.88-1.24]

0.615

B-cell cluster [47]

Intermediary vs Good

343

1.15 [0.74-1.79]

0.0692

3353

1.20 [1.04-1.38]

3.94E-05

Poor vs Good

1.64 [1.07-2.52]

1.38 [1.20-1.59]