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Table 1 Pathways Predicted to be altered by miR-155 Target Regulation

From: microRNA regulation of mammalian target of rapamycin expression and activity controls estrogen receptor function and RAD001 sensitivity

Pathway

p value

PDGFR-beta signaling pathway

2.77E-11

TGF-beta receptor signaling

1.74E-09

Signaling events mediated by hepatocyte growth factor receptor (c-Met)

6.00E-09

IL4-mediated signaling events

9.61E-08

CXCR4-mediated signaling events

2.22E-08

mTOR signaling pathway

4.37E-08

IGF1 pathway

7.71E-08

Regulation of retinoblastoma protein

9.30E-08

Signaling events mediated by stem cell factor receptor (c-Kit)

2.75E-07

AP-1 transcription factor network

2.76E-07

ErbB1 downstream signaling

3.70E-07

Neurotrophic factor-mediated Trk receptor signaling

5.56E-07

Direct p53 effectors

5.80E-07

FGF signaling pathway

6.75E-07

GMCSF-mediated signaling events

7.06E-07

  1. p value determined by size of miR-155 target data set, number of molecules in a pathway, and number of molecules in database. Determines probability that miR-155 targets are biased towards a particular pathway.
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Molecular Cancer

ISSN: 1476-4598