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Figure 4 | Molecular Cancer

Figure 4

From: miR-193a-3p regulates the multi-drug resistance of bladder cancer by targeting the LOXL4 gene and the Oxidative Stress pathway

Figure 4

The effects of a forced reversal of the miR-193a-3p or LOXL4 levels on the chemoresistance of 5637 and H-bc cells. A, The IC50 dosed drug-triggered cell death of 5637 cells transfected by miR-193a-3p mimic (3 PM) or the gene specific siRNAs versus the negative control (NC). B, The levels by qRT-PCR of both LOXL4 and SRSF2 mRNAs in the 3 PM, or siRNAs (single or in combination) transfected 5637 cells and the 3PA transfected H-bc cells versus the NC. C, The levels by Western analysis of both LOXL4 and SRSF2 proteins in the siRNA versus the negative control siRNA (NC) transfected 5637 cells. D, The drug-triggered cell death of the miR-193a-3p antagomiR (3PA) versus the NC transfected H-bc cells. E, The levels of both LOXL4 and SRSF2 mRNAs and proteins were measured by qPCR and Western analyses in the 3PA versus NC transfected H-bc cells. F, The effects of the forced reversal of both miR-193a-3p and LOXL4 levels on the apoptosis by FACS analysis of 5637 cells in plot and in the original. (*,P < 0.05; **,P < 0.01).

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Molecular Cancer

ISSN: 1476-4598