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Figure 3 | Molecular Cancer

Figure 3

From: MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer

Figure 3

Combination of MYC inhibitor and antiestrogen increased G1 cell cycle arrest in endocrine resistant cells. A, Top, ICI (100 nM), 10058-F4 (25 μM), or the combination significantly increased percentage of cells in G1 arrest and reduced percentage of cells in S phase in LCC1 (p < 0.001). Bottom, Representative cell count plots for propidium iodide (PI) in LCC1 cells are shown. B , Top, Only the combination of ICI and 10058-F4 induced significant increase in G1 arrest in LCC9 cells (p < 0.001). Bottom, Representative cell count plots for PI in LCC9 cells are shown. Graphs represent data that are presented as the mean ± SE for three independent experiments. ANOVA, p < 0.001; *p < 0.001 for indicated treatment versus vehicle control.

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Molecular Cancer

ISSN: 1476-4598