Table 3 The top 10 highest/lowest hazard ratios from OvMark screen of all Entrez Gene IDs (n = 20,016) using OS as the survival end point and the median cut-off
Gene symbol | Entrez gene ID | Previous association with ovarian cancer | Previous association with cancer | Hazard ratio | P-value* | Sample number | C-Index | P-value |
|---|---|---|---|---|---|---|---|---|
SNAI3 | 333929 | Yes [50] | Yes [51] | 0.61 | 0.03 | 827 | 0.62 | 2.0 × 10−4 |
VWA3A | 146177 | No | No | 0.63 | 0.02 | 610 | 0.59 | 2.1 × 10−3 |
DNAH12 | 201625 | No | No | 0.64 | 0.01 | 610 | 0.61 | 2.0 × 10−4 |
SERPINA2 | 390502 | No | No | 0.64 | 0.01 | 1293 | 0.64 | < 0.0001 |
TMEM181 | 57583 | No | No | 1.56 | 0.03 | 527 | 0.60 | 8.0 × 10−4 |
PCDP1 | 200373 | No | No | 0.65 | 8.96 × 10−3 | 827 | 0.62 | < 0.0001 |
ANKIB1 | 54467 | No | No | 1.53 | 0.04 | 527 | 0.60 | 3.2 × 10−3 |
C11ORF88 | 399949 | No | No | 0.66 | 0.01 | 910 | 0.62 | < 0.0001 |
FSHR | 2492 | Yes [52] | Yes [52] | 0.68 | 9.14 × 10−3 | 1833 | 0.60 | 1.0 × 10−3 |
TBC1D23 | 55773 | No | Yes [53] | 1.46 | 0.05 | 610 | 0.60 | 1.2 × 10−3 |