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Figure 2 | Molecular Cancer

Figure 2

From: MCRS1 overexpression, which is specifically inhibited by miR-129*, promotes the epithelial-mesenchymal transition and metastasis in non-small cell lung cancer

Figure 2

The drug resistance and generation of CD44+CSC-like cells in cultured NSCLC cells after MCRS1 silencing. (a) Assessment of the viability of EPLC-32 M1 and NCI-H292 cells after cisplatin treatment for 72 h. (b) Assessment of the viability of EPLC-32 M1 and NCI-H292 after cetuximab treatment for 72 h. (c) The expression of ABCB1 mRNA after MCRS1 depletion. (d) Flow cytometric analysis of CD44 expression in EPLC-32 M1 and NCI-H292 cells with or without MCRS1 knockdown. Luc: cells without MCRS1 silencing; Msh3: cells with stable MCRS1 silencing. *P <0.05 (one-way ANOVA and Student’s t-test).

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Molecular Cancer

ISSN: 1476-4598