Figure 1

CT antigen expression levels correlate with the clinical course of multiple myeloma. The expression levels of MAGE-C1/CT7 (A), MAGE-A3 (B) and MAGE-C2/CT10 (C) increased in eight patients who did not respond to treatment and showed non-remission courses with time. (D, E, F) The expression levels of the three CT antigen genes were reduced in 11 patients who responded to treatment. (G, H, I) Four patients with de novo disease experienced partial remission and then disease progression; the expression levels of the three CT antigen genes fell and then rose in two patients, while the other two patients showed increased expression levels before the disease progressed at later time points. (J, K, L) The expression levels of the three CT antigen genes were reduced or negative in 13 patients after auto-HSCT. In three patients who relapsed after auto-HSCT, one had an increased expression level of MAGE-A3, and the other two had increased expression levels of all three genes.