Figure 3
From: SOX1 down-regulates β-catenin and reverses malignant phenotype in nasopharyngeal carcinoma
SOX1 suppresses tumor formation in nude mice model. (A) CNE2 cells (1 × 106) virally transformed with vector-alone or SOX1 plasmid were injected into the left (vector-only) and right (SOX1) flank of nude mice, respectively (upper panel). Tumors were taken from mice of both the control group and SOX1 overexpression group after 20 days (lower panel). (B) Tumor growth curve of SOX1-overexpressing cells compared with that of vector-only cells. Points represent the mean tumor volumes of six independent experiments; bars represent the SD. (**p <0.01, ***p <0.001, Student’s t test) (C) Tumor weight from the vector-only and SOX1 groups decreased from 1.15 ± 0.20 g to 0.15 ± 0.04 g. The results were obtained from six independent experiments; bars represent the SD. (***p <0.001, Student’s t test).