P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer

Table 1 P7170 inhibits the growth of NSCLC patient-derived cancer cells

Tumor designation	Model #	Histology	Kras	PIK3CA	PTEN	IC50 (nM)
LXFA	1012	adenocarcinoma	wt	wt	wt	45
LXFA	1584	adenocarcinoma	NA	NA	NA	2
LXFA	586	adenocarcinoma	wt	wt	wt	9
LXFA	629	adenocarcinoma	wt	wt	wt	5.5
LXFA	677	adenocarcinoma	wt	wt	wt	300
LXFA	737	adenocarcinoma	wt	wt	wt	300
LXFA	749	adenocarcinoma	wt	wt	wt	17
LXFE	1422	Squamous cell carcinoma	wt	wt	wt	8.5
LXFE	470	Squamous cell carcinoma	wt	E545K heterozygous	wt	50
LXFE	646	Squamous cell carcinoma	wt	wt	wt	100
LXFL	1674	Large cell	G12C homozygous	wt	wt	30
LXFL	430	Large cell	wt	wt	wt	3
LXFL	529	Large cell	wt	wt	wt	50

Various patient tumor xenograft-derived NSCLC cells treated with P7170 at log concentrations (range: 0.01 nM – 1 μM) followed by growth in soft-agar to evaluate colony formation. Description of patient’s tumor histology sub-type, mutation status, and IC₅₀ of P7170 in these tumor xenograft-derived cells by soft-agar colony formation is shown.

ISSN: 1476-4598