P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer

Table 2 P7170 decreased growth of NSCLC cell line-derived tumor xenografts

Percent tumor growth inhibition in NSCLC-derived xenografts
P7170 ( *p.o., QD*)	H1650	H1975	H460
5 mg/kg	70% (p < 0.001)	45% (p < 0.01)	53% (p < 0.001)
15 mg/kg		92% (p < 0.001)	66% (p < 0.001)
20 mg/kg			88% (p < 0.0001)
Duration of treatment	15 days	13 days	11 days
Tumor volume at the beginning of treatment ~ 100 mm3

Nude mice bearing xenografts of human NSCLC cell lines H1650, H1975, or H460 were treated with P7170 at indicated doses for 10 – 15 days (p.o., QD). All mice maintained body weight with a loss not more than 10%.

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