Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation

Table 2 Prognostic factors for overall survival by multivariate Cox regression analysis in BRCA1-mutated breast cancer

Variable	RR	95%CI	P
Age at diagnosis (> 50 y vs ≤ 50 y)	1.059	0.982-1.143	0.137
Menstrual status (Post vs Pre)	0.258	0.043-1.542	0.138
Tumor size (> 5 cm vs ≤ 5 cm)	0.389	0.107-1.413	0.151
Histological grade (III vs I-II)	2.628	0.642-10.761	0.179
LN status (Pos vs Neg)	3.511	1.074-11.481	0.038
ER status (Pos vs Neg)	0.561	0.123-2.554	0.455
PR status (Pos vs Neg)	1.558	0.420-5.775	0.507
c-erbB-2 status (Pos vs Neg)	1.429	0.422-4.832	0.566
p53 status (Pos vs Neg)	0.437	0.112-1.703	0.233
Ki67 status (Pos vs Neg)	0.628	0.120-3.271	0.580
E-cadherin status (Pos vs Neg)	0.651	0.158-2.678	0.552
DNMT1 methylation (M vs UM)	1.386	0.337-5.699	0.651

Post, postmenopausal; Pre, premenopausal; LN, lymph node; ER, estrogen receptor; PR, progesterone receptor; Pos, positive; Neg, negative; M, methylated; UM, unmethylated; RR, relative risk; CI, confidence interval.

ISSN: 1476-4598