Skip to main content

Table 2 Prognostic factors for overall survival by multivariate Cox regression analysis in BRCA1-mutated breast cancer

From: Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation

Variable RR 95%CI P
Age at diagnosis (> 50 y vs ≤ 50 y) 1.059 0.982-1.143 0.137
Menstrual status (Post vs Pre) 0.258 0.043-1.542 0.138
Tumor size (> 5 cm vs ≤ 5 cm) 0.389 0.107-1.413 0.151
Histological grade (III vs I-II) 2.628 0.642-10.761 0.179
LN status (Pos vs Neg) 3.511 1.074-11.481 0.038
ER status (Pos vs Neg) 0.561 0.123-2.554 0.455
PR status (Pos vs Neg) 1.558 0.420-5.775 0.507
c-erbB-2 status (Pos vs Neg) 1.429 0.422-4.832 0.566
p53 status (Pos vs Neg) 0.437 0.112-1.703 0.233
Ki67 status (Pos vs Neg) 0.628 0.120-3.271 0.580
E-cadherin status (Pos vs Neg) 0.651 0.158-2.678 0.552
DNMT1 methylation (M vs UM) 1.386 0.337-5.699 0.651
  1. Post, postmenopausal; Pre, premenopausal; LN, lymph node; ER, estrogen receptor; PR, progesterone receptor; Pos, positive; Neg, negative; M, methylated; UM, unmethylated; RR, relative risk; CI, confidence interval.