Figure 4
From: Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells
Induction of IPP and ApppI in bisphosphonate-stimulated breast cancer cells by probenecid. MCF-7 (A) and T47D (B) cells were treated with ZA (zoledronic acid), RIS (risedronate), IBN (ibandronate), ALN (alendronate) alone and in combination with probenecid (Prob). All data are expressed as means of three independent experiments ± SEM. The induction of IPP (black bars) and ApppI (grey bars) in BP stimulated cells by Prob is shown. Significances were calculated with the Mann–Whitney U test (**p < 0.005, *p < 0.05).