Figure 4

Low correlation between microRNA and corresponding host gene expression. Expression of genes hosting microRNAs was obtained from microarray data and expression of corresponding microRNAs was obtained from microRNA-seq data. The hypoxic regulation at 32 h and 48 h for both groups was then compared from two different perspectives. First, hosting genes were sorted in 3 groups at each time point: significantly down-regulated (down), not significantly regulated (unv) and significantly up-regulated (up). The fold-change distribution for each group of genes at 32 h and 48 h of hypoxia compared to normoxia is shown in boxplots (A). For each group of genes, the fold-change distribution of corresponding microRNAs at 32 h and 48 h compared to normoxia is also shown in boxplots for comparison (B). Second, microRNAs hosted within genes were sorted in 3 groups according to their hypoxic regulation at 32 h and 48 h: significantly down-regulated (down), not significantly regulated (unv) and significantly up-regulated (up). The fold-change distribution for each group of microRNAs at 32 h and 48 h of hypoxia compared to normoxia is shown in boxplots (C). For each group of microRNAs, the fold-change distribution of corresponding host genes at 32 h and 48 h compared to normoxia is also shown in boxplots for comparison (D). All fold-change distributions are shown in linear scale.