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Figure 6 | Molecular Cancer

Figure 6

From: High calcium concentration in bones promotes bone metastasis in renal cell carcinomas expressing calcium-sensing receptor

Figure 6

Signaling pathways involved in the calcium dependent bone metastasis of RCC. Results obtained in this study are marked with an arrow: arrow upwards means enhancement, arrow downwards means reduction. In cells obtained from patients who developed bone metastases within 5 years after nephrectomy, the expression and activity of CaSR, JNK, paxillin, p38α, PLCγ1 and AKT was enhanced after calcium treatment, PTEN expression was reduced, resulting in an enhanced migration and proliferation.

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Molecular Cancer

ISSN: 1476-4598