Table 1 Clinical and pathological characteristics

Frequency of mutations

V600E

47(74.6)

Q61R

16 (40)

V600K

12 (19)

Q61K

12 (30)

V600R/L

2 (3.1)

Q61L

6 (15)

Unknown

2 (3.1)

Q61H

4 (10)

G12D/V

2 (5)

Sex

Male

42 (66)

25 (62)

22 (54)

0.21

Female

21 (33)

15 (38)

19 (46)

Median age (years)

57.6

68.2

66.3

<0.0001

LDH

Elevated

28

19

20

0.6

Normal

24

6

12

Unknown

11

15

9

M stage

M1a

13

8

9

0.3

M1b

11

14

9

M1c

39

18

23

Soft tissue and skin metastasis

23 (37)

28 (70)

17 (41)

0.0025

Lymph node metastasis

29 (46)

30 (75)

25 (61)

0.01

Lung metastasis

41 (65)

24 (60)

27 (66)

0.8

Liver metastasis

25 (39)

11 (27)

17 (41)

0.3

Bone metastasis

17

7

6

0.3

CNS metastasis

31 (49)

16 (40)

16 (39)

0.5

Median survival from diagnosis of stage IV disease

18.3

13.0

19.6

0.17