Table 1 List of transcription factors differentially expressed between adjacent and healthy mucosa samples
From: Aberrant gene expression in mucosa adjacent to tumor reveals a molecular crosstalk in colon cancer
Gene symbol | Connections | DEG connections | Rank | P-value | Eccentricity | Closenness centrality | Healthy mucosa network |
|---|---|---|---|---|---|---|---|
FOSB | 4 | 4 | 1.000 | <1.00E-04 | 9 | 0.209 | NO |
JUN | 2 | 2 | 1.000 | <1.00E-04 | 11 | 0.151 | NO |
NR4A2 | 5 | 5 | 1.000 | <1.00E-04 | 9 | 0.204 | NO |
OSR2 | 12 | 12 | 1.000 | <1.00E-04 | 8 | 0.234 | NO |
ZBTB16 | 1 | 1 | 1.000 | <1.00E-04 | 9 | 0.200 | NO |
EGR2 | 10 | 9 | 0.900 | <1.00E-04 | 8 | 0.247 | NO |
NR4A3 | 9 | 8 | 0.889 | <1.00E-04 | 8 | 0.249 | NO |
EBF1 | 162 | 143 | 0.883 | <1.00E-04 | 7 | 0.294 | YES |
HEY2 | 24 | 21 | 0.875 | <1.00E-04 | 8 | 0.266 | NO |
NR4A1 | 16 | 14 | 0.875 | <1.00E-04 | 8 | 0.240 | NO |
PRRX1 | 30 | 26 | 0.867 | <1.00E-04 | 7 | 0.289 | NO |
EGR1 | 13 | 11 | 0.846 | <1.00E-04 | 9 | 0.217 | YES |
FOS | 6 | 5 | 0.833 | <1.00E-04 | 10 | 0.178 | NO |
JUNB | 5 | 4 | 0.800 | <1.00E-04 | 10 | 0.178 | NO |
MEOX2 | 75 | 60 | 0.800 | <1.00E-04 | 7 | 0.303 | NO |
ZFPM2 | 133 | 106 | 0.797 | <1.00E-04 | 7 | 0.296 | NO |
ERG | 76 | 60 | 0.789 | <1.00E-04 | 8 | 0.287 | NO |
TSHZ2 | 109 | 85 | 0.780 | <1.00E-04 | 7 | 0.302 | NO |
FOXC1 | 27 | 21 | 0.778 | <1.00E-04 | 8 | 0.268 | NO |
HLF | 84 | 65 | 0.774 | <1.00E-04 | 7 | 0.301 | NO |
MEIS2 | 133 | 100 | 0.752 | <1.00E-04 | 8 | 0.305 | NO |
CREB5 | 32 | 24 | 0.750 | <1.00E-04 | 8 | 0.278 | NO |
PRDM6 | 83 | 62 | 0.747 | <1.00E-04 | 7 | 0.293 | NO |
GLIS2 | 79 | 58 | 0.734 | <1.00E-04 | 7 | 0.302 | NO |
HAND2 | 138 | 101 | 0.732 | <1.00E-04 | 7 | 0.289 | NO |
EGR3 | 11 | 8 | 0.727 | <1.00E-04 | 8 | 0.263 | NO |
SOX18 | 40 | 29 | 0.725 | <1.00E-04 | 7 | 0.274 | NO |
ZNF423 | 79 | 57 | 0.722 | <1.00E-04 | 8 | 0.303 | YES |
PHOX2B | 60 | 42 | 0.700 | <1.00E-04 | 8 | 0.275 | YES |
KLF7 | 133 | 92 | 0.692 | <1.00E-04 | 7 | 0.313 | NO |
GLI3 | 217 | 150 | 0.691 | <1.00E-04 | 7 | 0.325 | NO |
MEIS1 | 113 | 77 | 0.681 | <1.00E-04 | 8 | 0.301 | YES |
KLF2 | 15 | 10 | 0.667 | <1.00E-04 | 8 | 0.261 | YES |
TSHZ3 | 80 | 52 | 0.650 | <1.00E-04 | 8 | 0.302 | YES |
NKX2-3 | 75 | 47 | 0.627 | <1.00E-04 | 8 | 0.290 | NO |
BNC2 | 252 | 148 | 0.587 | <1.00E-04 | 7 | 0.334 | NO |
PITX2 | 26 | 15 | 0.577 | <1.00E-04 | 9 | 0.244 | YES |
PRDM8 | 70 | 40 | 0.571 | <1.00E-04 | 7 | 0.304 | YES |
NR2F2 | 141 | 78 | 0.553 | <1.00E-04 | 7 | 0.334 | YES |
TSC22D3 | 29 | 16 | 0.552 | <1.00E-04 | 7 | 0.282 | NO |
PBX3 | 186 | 102 | 0.548 | <1.00E-04 | 7 | 0.337 | YES |
ZEB1 | 264 | 139 | 0.527 | <1.00E-04 | 7 | 0.343 | YES |
FOXF1 | 62 | 31 | 0.500 | <1.00E-04 | 7 | 0.312 | YES |
ZNF532 | 110 | 52 | 0.473 | <1.00E-04 | 7 | 0.326 | YES |
CAMTA1 | 68 | 30 | 0.441 | <1.00E-04 | 7 | 0.318 | YES |
JAZF1 | 172 | 74 | 0.430 | <1.00E-04 | 7 | 0.334 | NO |
AFF3 | 31 | 11 | 0.355 | <1.00E-04 | 7 | 0.295 | YES |
NFIC | 131 | 43 | 0.328 | <1.00E-04 | 7 | 0.339 | YES |
ZEB2 | 74 | 24 | 0.324 | <1.00E-04 | 7 | 0.324 | YES |
TCF4 | 408 | 129 | 0.316 | <1.00E-04 | 6 | 0.371 | YES |
BCL6 | 36 | 11 | 0.306 | <1.00E-04 | 7 | 0.309 | NO |
NR1H4 | 77 | 22 | 0.286 | <1.00E-04 | 8 | 0.282 | YES |
MAFB | 125 | 23 | 0.184 | <1.00E-04 | 6 | 0.313 | YES |
HOXB13 | 93 | 14 | 0.151 | <1.00E-04 | 8 | 0.264 | NO |
ATF3 | 4 | 3 | 0.750 | 0.0003 | 10 | 0.184 | NO |
ZBTB20 | 149 | 13 | 0.087 | 0.0183982 | 7 | 0.356 | YES |
THRB | 12 | 2 | 0.167 | 0.0986901 | 8 | 0.259 | YES |
HOXB6 | 2 | 0 | 0.000 | 1 | 8 | 0.227 | YES |
IFI16 | 5 | 0 | 0.000 | 1 | 7 | 0.247 | YES |
NEUROD1 | 12 | 0 | 0.000 | 1 | 8 | 0.236 | NO |