Table 1 DNL-Rap conjugates used in the study
Code | Target | AD2-module | DDD2-module |
|---|---|---|---|
(Rap)2-E1-(Rap)2 | Trop-2 | CH3-AD2-IgG-hRS7 | Rap-DDD2 |
(Rap)2-22-(Rap)2 | CD22 | CH3-AD2-IgG-hLL2 | Rap-DDD2 |
(Rap)2-20-(Rap)2 | CD20 | CH3-AD2-IgG-hA20 | Rap-DDD2 |
(Rap)2-74-(Rap)2 | CD74 | CH3-AD2-IgG-hLL1 | Rap-DDD2 |
(Rap)2-C2ā(Rap)2 | HLA-DR | CH3-AD2-IgG-hL243 | Rap-DDD2 |
(Rap)2-14-(Rap)2 | CEACAM5 | CH3-AD2-IgG-hMN-14 | Rap-DDD2 |
(Rap)2-E1*-(Rap)2 | Trop-2 | CK--AD2-IgG-hRS7 | Rap-DDD2 |
(Rap)2-22*-(Rap)2 | CD22 | CK-AD2-IgG-hLL2 | Rap-DDD2 |