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Table 2 Comparison of in vitro potency of (Rap) 2 -E1-(Rap) 2 vs. Rap(Q)-hRS7

From: Trop-2-targeting tetrakis-ranpirnase has potent antitumor activity against triple-negative breast cancer

Agents

EC50(nM)a

Ā 

MDA-MB-468

MCF-7

SKBR-3

HCC1806

BT-20

MDA-MB-231

HCC1395

(Rap)2-E1-(Rap)2

0.03

0.1

1.29

0.19

0.18

>50

~100

Rap(Q)-hRS7

3.8b

>100b

>100b

10.1

>100

NDc

NDc

  1. aHalf maximal effective concentration; bFrom previous results [34]; cNot determined.
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Molecular Cancer

ISSN: 1476-4598