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Figure 7 | Molecular Cancer

Figure 7

From: Regulation of CDKN2B expression by interaction of Arnt with Miz-1 - a basis for functional integration between the HIF and Myc gene regulatory pathways

Figure 7

Model based on the presented data. We hypothesize that in U2OS cells under normoxia, a complex consisting of Miz-1/Arnt and Hif1α and/or Hif2α is anchored to the CDKN2B proximal promoter via Miz-1. A repressive complex of Myc/Max, which competes for the same interaction surface on Miz-1, counteracts this activity, and the mutually exclusive interaction of these complexes ensures adequate levels of CDKN2B at normoxia (left). Upon hypoxia, the examined complexes binding at high O2 pressure leave the CDKN2B promoter, allowing yet unknown factors to interact with Miz-1 or to act by other means to repress the expression of CDKN2B (right).

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Molecular Cancer

ISSN: 1476-4598