Figure 5

B16F10 cell induced tumor growth in BALB/c mice in the presence or absence of complex 3. A, Mice toxicity survival curve upon administration of various doses of complex 3. B, Treatment series depicting the sequence followed for complex 3 administration, following tumor growth. C, Percentage survival of tumor carrying mice upon administration of complex 3 (0, 5, 10 mg/kg body weight of mice) over a period of 60 days. D, Tumor size variation upon administration of complex 3 (0, 5, 10 mg/kg body weight of mice). E-F, body weight (g) and tumor volume (cm³) of mice administered with complex 3 (0, 5 and 10 mg/kg weight of mice). G-I, H/E staining (→ depicting the intact and fragmented nuclei in the control and the treated tumor sections respectively), tumor weight (g) and mitotic index of tumors excised from mice administered with complex 3 (0, 5 and 10 mg/kg body weight). The survival rate data were analyzed by Kaplan-Meier plots. Values are mean ± S.D and represent one of the 3 representative experiments . *P < 0.05 and **P < 0.01.