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Figure 4 | Molecular Cancer

Figure 4

From: RETRACTED ARTICLE: Exemestane blocks mesothelioma growth through downregulation of cAMP, pCREB and CD44 implicating new treatment option in patients affected by this disease

Figure 4

Hypothesized mechanism of action of exemestane on MPM cells. The GPCR receptor binds estrogen and cause estrogen-mediated cAMP stimulation and PI3K cascade. PI3K phosphorylates AKT (pAkt) which in turn regulates Bcl-xL, anti-apoptotic protein. cAMP stimulates PKA, which in turn activates CREB that translocates into the nucleus and acts as a transcription factor for CD44. The action of exemestane is carried out by reducing the levels of estradiol, its binding with GPCR and related downstream pathway.

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Molecular Cancer

ISSN: 1476-4598