Figure 1
From: Autophagic flux determines cell death and survival in response to Apo2L/TRAIL (dulanermin)
p62 expression in human prostate cancer (PCa) samples. (A and B) immuno-histochemical staining for p62 in PCa tissue microarrays. Black arrow: nuclear p62; red arrow: cytoplasmic; blue arrow: no staining (a1), benign prostate tissue with nuclear p62 staining; (a2), benign prostate tissue with nuclear p62 staining (a3), benign prostate tissue displaying nuclear p62 staining and PCa with cytoplasmic staining; (b1), PCa Gleason score (GS 4 + 3) 7 with both nuclear (black arrow) and cytoplasmic (red arrow) staining; (b2), PCa Gleason score (4 + 4) 8 with cytoplasmic staining (red arrow). (C) Nuclear (N) and cytoplasmic (C) p62 expression in benign and various GS (D) mRNA expression analysis in benign prostate tissue (benign prostate hyperplesia) and various GS human PCa samples from the Oncomine database (p < 0.001).