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Figure 1 | Molecular Cancer

Figure 1

From: miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer

Figure 1

miR-630 expression decreases with both acquired- and innate resistance. (A) miR-630 expression was significantly decreased in cells with acquired lapatinib resistance ((i) HCC1954-LR and (ii) SKBR3-LR) and acquired neratinib-resistance ((iii) HCC1954-NR) compared to their age-matched control cells (HCC1954-Ag, SKBR3-Ag). miR-630 expression was also significantly decreased in cells with innate resistance to lapatinib ((iv) MDA-MB-453) compared to cells with innate sensitivity (SKBR3). (B) Extracellular expression of miR-630 was also assessed in the corresponding conditioned medium of these cells and trends followed that of the cells. All results represent biological repeats n = 3 ± SEM, where * p <0.05, ** p <0.01, *** p <0.001.

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Molecular Cancer

ISSN: 1476-4598