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Figure 5 | Molecular Cancer

Figure 5

From: Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia

Figure 5

Expression levels of murine genes quantified by qPCR in tumor and normal colon tissue, and Zfp277 protein expression in tumor sections from WT, Chrm3-/-, Chrm1-/-and dual KO mice. A: Colon tumors. N = 3 mice/genotype. B: Normal colon. N = 3 mice/genotype. Shown is the fold difference in gene expression normalized to glyceraldehyde-3-phosphate dehydrogenase (Gapdh) levels in tissue from Chrm3-/-, Chrm1-/- and dual KO mice relative to that in tissue from WT mice. Error bars, S.E. (* indicates P < 0.05). C: Representative images show immunohistochemical staining with anti-Zfp277 antibody on tumor sections from WT, Chrm3-/-, Chrm1-/- and dual KO mice. Graph shows quantification of Zfp277 staining in tumor sections. Data shown represent mean ± S.E. from four mice per genotype (* indicates P < 0.05). Size bars = 100 micrometers.

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Molecular Cancer

ISSN: 1476-4598