Figure 1
From: MicroRNA-155 as an inducer of apoptosis and cell differentiation in Acute Myeloid Leukaemia
miR-155 expression in AML samples and normal haematopoietic cells. (A) miR-155 expression levels by qRT-PCR in normal bone marrow (5 samples) and AML samples with FLT3-ITD (13 samples) or wildtype (14 samples), values are normalized to the mean of the normal bone marrow samples (B) miR-155 expression in selected AML cell lines and PBMCs, presented as mean fold change + SEM relative to OCI-AML3 (baseline set at 1, white bar). Unpaired Two Tailed T-Test compared to expression levels in MV4-11 cells, *p < 0.05, **p < 0.001. n = 3-5 (C) miR-155 expression levels of haematopoietic progenitor subsets isolated from four normal mobilized peripheral blood donors, presented as mean + SEM relative to GMP. No statistical difference detected between groups using Paired t-test. HSC- haematopoietic stem cell; MPP- multipotent progenitor; CMP- common myeloid progenitor; GMP- granulocyte monocyte progenitor.