Figure 7
From: MicroRNA-155 as an inducer of apoptosis and cell differentiation in Acute Myeloid Leukaemia
Potential regulatory mechanisms of miR-155 in AML. Model of miR-155-mediated gene regulation in FLT3-WT AML, where its expression acts to induce myeloid differentiation and caspase-3 dependent apoptosis. In AML cells miR-155 overexpression was found to decrease the expression of cMYC and MEIS1/GFI1, potentially leading to the phosphorylation of JNK and/or the activation of p27/kip1 and activation of the apoptosis cascade. The increase in AP-1 and TRIB2 genes may be caused by an intermediary, such as JARID2 inhibition, and may have functions in regulating AML cell differentiation and apoptosis.