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Figure 2 | Molecular Cancer

Figure 2

From: Targeting gallbladder cancer: oncolytic virotherapy with myxoma virus is enhanced by rapamycin in vitro and further improved by hyaluronan in vivo

Figure 2

Effect of rapamycin combined with myxoma virus on human gallbladder cancer cell lines in vitro and in vivo . A. The effect of MYXV + Rap on GBC-SD and U251 cells. Cell viability was measured by WST-1 assay 72 h after vMyx-gfp infection in the presence (+) or absence (−) of 20 ng/mL or 100 ng/mL Rap (*, P < 0.05 when compared with Myx alone group). B, C. In vivo mouse xenograft model of gallbladder cancer (GBC-SD) or glioma (U251) with UV-inactivated Dead Virus (DV), Rapamycin (Rap), vMyx-gfp (Myx), or Myx + Rap. Tumor areas were evaluated over time by caliper measurement (*, P < 0.05 of Myx + Rap vs. Myx). D. Relative tumor area was measured to compare the growth pattern of xenografted mice implanted with GBC-SD or U251 (*, P < 0.05 of U251 vs. GBC-SD), which was calculated by dividing the tumor area found after combination therapy by that found after control treatment at each time point E, F. Kaplan-Meier survival analysis of mice treated with DV, Rap, Myx, or Myx + Rap in xenografted mice implanted with GBC-SD or U251.

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Molecular Cancer

ISSN: 1476-4598